ABSTRACT
Objective To investigate the epidemiological characteristics of the group A rotavirus (RV) among the children with diarrhea in Shenzhen ,in order to provide reference for clinical diagnosis and treatment .Methods Stool samples were collected for RV detection from children with diarrhea .The results were analyzed .Results A total of 3 509 cases of children with RV infection were checked out from 14 511 cases of children with diarrhea ,with the infection rate accounting for 24 .18% .RV infection occurred all year around ,and the infection peak was November ,December and January .RV infected children mainly distributed in the age group of 6 months to 2 years .Conclusion RV infection in children is a universal problem in Shenzhen .Clinic should pay attention to it .
ABSTRACT
<p><b>BACKGROUND</b>Chemotherapy is main treatment of small cell lung cancer (SCLC). This aim of this study is to evaluate the effects and the adverse effects of HCE regimen (hydroxycamptothecin + etoposide + carboplatin) in treatment of SCLC.</p><p><b>METHODS</b>Patients with previously untreated SCLC were randomized into two groups: HCE group (treated by HCE regimen) and EP group (treated by etoposide and cisplatin). The chemotherapeutic effects and the adverse effects were compared between two groups.</p><p><b>RESULTS</b>A total of 71 patients could be evaluated. The overall response rate was 90.3% (28/31) for HCE group with 17 complete response (CR) and 11 partial response (PR), and 70.0% (28/40) in the EP group with 9 CR and 19 PR. The CR was significantly different between two groups. The median survival time of the HCE group and EP group were 11.5 and 25 months respectively. The 1-year survival rate was 72.4% vs 69.4% (P > 0.05), 2-year survival rate was 51.7% vs 44.4% (P < 0.05), and 3-year survival rate was 40.0% vs 29.2% (P < 0.05). Myelosuppression, diarrhea and vomiting were the main toxicities in two groups. The incidence of myelosuppression was higher in the HCE group than that in the EP group but without statistical difference (P > 0.05), whereas the incidence of nausea and vomiting were significantly lower than that in the EP group (P < 0.01).</p><p><b>CONCLUSIONS</b>HCE regimen is an effective regimen for previously untreated SCLC with high CR and slight toxicity. It may be worthy of further clinical investigation.</p>